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Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders

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the delivery system includes those which by-pass gut and liver and thus first pass effect / metabolism

It first appeared in the tropics' malarial zones, where carriers benefit from an evolutionary advantage by being shielded from malaria death

36 Because of its high incidence among populations in which malaria was once endemic, G6PD deficiency is thought to have conferred a selective advantage against infection by falciparum malaria