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Two canonical pathways represent the primary mechanisms for activation and degranulation of mast cells: activation of the IgE pathway via receptor cross-linking by antibodies targeting the high-affinity IgE receptor 7 (FcRI) or IgE itself, and activation of an IgE-independent pathway via MRGPRX2
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doi: 10.1016/j.jhin.2015.10.024 111 ClarkFMDehrA
The heme connection: linking erythrocytes and macrophage biology
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