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A recent retrospective study involving a large sample size of 1,890,020 diabetic patients found that GLP-1RAs were associated with a significantly lower risk of hepatocellular carcinoma compared to insulin and other diabetic medications over a 5-year follow-up period ( Pre-clinical studies investigating the impact of GLP-1 RAs specifically on breast cancer progression have produced conflicting results, which vary based on the receptor status of the cancer cell lines studied ( in vitro ( in vitro study by Zhao et al., liraglutide reduced cell proliferation and increased cell apoptosis in estrogen receptor-positive breast cancer cells ( in vitro studies by Alanteet et al

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It is not recommended for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2