The participants on tirzepatide also lost more body fat (9.7% vs 5.9%)
Enrolled patients had a baseline or recent liver biopsy showing clinically significant MASLD (metabolic dysfunction-associated steatotic liver disease), defined as MASH with fibrosis stage 2 or 3 and a non-alcoholic fatty liver disease (NAFLD) Activity Score (NAS) 4 with a score of 1 or more in steatosis, lobular inflammation, and hepatocyte ballooning
For people with type 2 diabetes receiving concomitant insulin or sulfonylureas, there is a theoretical risk of hypoglycaemia based on class experience with GLP-1-based therapies
However, a significant change in the law in November 2018 made it legal for specialist doctors on the General Medical Council (GMC) register to prescribe unlicensed cannabis-based medicinal products containing THC
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