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Nevertheless, the annual distribution of adverse event reports revealed that tirzepatide exceeded semaglutide in 2023 and early 2024, consistent with its rising clinical use [107]

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Moreover, the impact of individual differences and environmental factors on OA has not been fully considered, with many studies limited to specific populations and lacking support from global multicenter, large-sample data

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The inhibitor action of GLP-1 on glucagon levels is often over-looked in favor of its role as an insulin secretagogue, but it is clear that pharmacologically this is one mechanism by which GLP-1r agonists improve glycemia in T2DM patients (86)