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This small, butterfly-shaped gland in your neck produces hormones that tell every cell in your body how fast to work

It also had a positive effect on body weight, with participants on IcoSema losing almost 8 pounds compared to those taking basal-bolus insulin who gained roughly 7 pounds

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The data on this is limited for retatrutide since it is newer, but the general pattern with GLP-1 agonists suggests that maintaining weight loss after stopping requires lifestyle modifications regardless of which compound you used