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Genetic counseling can help parents understand the risks of passing the disorder to their children and explore options such as prenatal testing

Recent clinical research has increasingly pointed to a profound cellular energy crisis driven by severe oxidative stress and the depletion of a critical molecule called glutathione

Studies have shown significantly reduced GPX3 mRNA levels in chondrocytes from KBD patients, where elevated methylation of CpGs in the GPX3 gene suppresses its transcription, reducing antioxidant function and promoting chondrocyte apoptosis, thus accelerating KBD progression [205,206]

Oh et al., 2013)

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Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury