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This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]

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Moreover, environmental factors and lifestyle choices can reduce glutathione levels

doi: 10.3389/fncel.2022.855161 30 DarwishS

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In addition to mitochondrial and phagocyte NADPH oxidases, ROS can also be generated by inflammation and gut dysbiosis (Figure 1)