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Conservative management strategies include: Optimize gastrointestinal function: Address constipation proactively with adequate hydration (individualized to the patient's cardiovascular and renal status), dietary fiber supplementation, and when necessary, osmotic laxatives such as polyethylene glycol

The authors noted that a key limitation of the study is that it was based on US population data and therefore may not be generalizable to countries with lower rates of obesity and metabolic disease

Nacalei Tesque, Kyoto, Japan) using a micro-syringe with a 32G needle (Ito, Shizuoka, Japan) and then sacrificed at 10 h and 48 h post-administration to investigate proinflammatory gene expression and microglial activation, respectively

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