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MD Anderson Advanced Microscopy Core Facility

doi: 10.1016/S0016-5085(12)60176-0

Four weeks of moderate-intensity treadmill exercise significantly inhibited the activation of the STING signaling pathway in the damaged cortex of traumatic brain injury mice, downregulated the expression of TFR1, FTH, and ACSL4, upregulated FPN, System Xc , GPX4, and GSH expression, and reduced levels of 4-HNE, MDA, and Fe 2+

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It is important to mention that, although COX-2 has traditionally been seen as an enzyme that is expressed only under pathological conditions, it has detrimental effects on the pathophysiology of diseases such as Alzheimers disease [238]