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In the SELECT CV outcome trial, which included patients aged 45 years or older with a body mass index (BMI) 27.0 kg m 2 and established ASCVD but without diabetes, those treated with the glucagon-like peptide-1 receptor agonist (GLP-1RA), semaglutide 2.4 mg, had a 20% MACE reduction compared with those receiving placebo on top of standard of care 12

Internal documents emerging through litigation discovery suggest the company failed to implement stronger safety warnings about gastrointestinal risks despite being well aware of the off-label prescribing trends and choosing to prioritize market expansion

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doi: 10.1016/j.resp.2016.03.007

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