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Younger patients and those with untreated depression appear at slightly elevated risk, though absolute numbers remain low

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Excess weight and obesity significantly raise the risk of cardiovascular diseases, insulin resistance, type 2 diabetes, and metabolic syndromes

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Morin, the PPAR agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis

These methods collectively enhance the internal validity of the findings, attempt to mitigate observed confounding, as well as help understand the impact of confounding due to unmeasured factors