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Am J Physiol Physiol 297(6):F1647F1655 Meier JJ (2012) GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

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While these treatments offer incredible health benefits, rapid fat loss can leave the face appearing gaunt, characterized by skin laxity and volume depletion in the cheeks, temples, and mid-face

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Further research is needed to investigate the potential causal links between GLP-1RAs and PI through other underlying mechanisms

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Carbonated beverages can increase bloating

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Similarly, the ICV infusion of liraglutide stimulates BAT thermogenesis and white adipose tissue browning

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As we move toward a new era of oral therapeutics, how might this shift our long-term treatment algorithms and conversations with patients about managing obesity as the chronic disease it is?

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