Experimental evidence demonstrated that treatment with (Ex-4)2-Fc promotes the conversion of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages, leading to increased expression of anti-inflammatory factors and significant reductions in pro-inflammatory markers
doi:10.1056/NEJMoa1509225 299
Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL
Combining treatments : Many patients get the best results by combining GLP-1 with diet, exercise, and, if needed, cholesterol medications like statins
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The conflicting safety signal One real-world evidence study found that patients receiving GLP-1 receptor agonists had higher risks of certain autoimmune conditions, including ulcerative colitis, rheumatoid arthritis, autoimmune thyroiditis, ankylosing spondylitis, and psoriasis, compared to those on DPP-4 inhibitors