Hormonal birth control methods, including pills, patches, and rings, rely on consistent hormone levels to prevent ovulation and create an environment that stops fertilization
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
Who Might Be Considered for Dual TherapyAnd Why Caution Applies Patients with severe obesity, type 2 diabetes, and proven inadequate response to maximal-dose monotherapy are the only theoretical candidates
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H., Chong J
