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Quality control of inductively coupled plasmatriple quadrupole mass spectrometer measurements was ensured through a combination of repeat measurements of: Acid blanks A quality control standard made from 1,000 mg l 1 High-Purity Standards multi-element standard solutions A tenfold dilution of the CRM-TMDW (trace metal drinking water) from High-Purity Standards Analyte measurements were normalized to the internal standard Iridium ( 193 Ir) to account for instrument drift and matrix effects, and measurements were subsequently blank corrected by removing the average analyte intensity of repeat blank measurements

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Previous studies also demonstrated that ACNs from maize counteracted liver ROS directly, increased superoxidase dismutase 1 (SOD-1) and ameliorated liver damage, indicating that the observed reduction in oxidative stress can be attributed to the ROS scavenging activity of cyanidin-3-O-glucoside (Magaa-Cerino et al., 2020)

TDD improves drug concentration at the targeted location while minimizing side effects and strengthening treatment efficacy [170]

Microglia isolation Details were available in the Additional file 1: Data Supplement

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