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Kyneurine, another oncometabolite [172, 173], was found to have significantly higher median values in the urine of PC patients ( n = 101) than in controls ( n = 52) [54]

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Furthermore, in streptozocin (STZ i.c.v) -induced AD rats (77) and APP/PS1 mice (78), DPP-4 inhibitors sitagliptin and saxagliptin were observed to have the ability to eliminate A accumulation, clear abnormal phosphorylation of tau, and improve brain mitochondrial dysfunction probably through activation of AMPK in neuronal cells (66)