GLP-1 receptor activation slows gastric emptying (making food stay in the stomach longer, which extends satiety), reduces glucagon secretion (lowering blood sugar), and acts on hypothalamic neurons to reduce hunger drive
Health Canada won't approve it as a drug, but it slips through as a compounded natural health product, where the federal safety check basically doesn't happen
Diabetologia 65(1):206215 Wei Y, Richardson TG, Zhan Y, Carlsson S (2023) Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study
Acetylation of p53 protein at lysine 120 up-regulates Apaf-1 protein and sensitizes the mitochondrial apoptotic pathway
Osteoarthritis, especially in the knees, hips and hand is a very common joint problem with over half a billion people in the world living with this condition that can affect the ability to move freely (70)
Sources1&2: KPMG analysis of data from U.S