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R 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkyl-NR 5 R 6 , C 1 -C 6 alkyl-OR 5 , or C 1 -C 6 alkylC 3 -C 6 cycloalkyl

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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

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(1, 6, 7 8) So, Does Vitamin B12 Give You Energy

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