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A serotonin 5-HT 2A receptor antagonist was shown to reduce neuronal proliferation, and chronic administration of a 5-HT 1A receptor agonist increased neuronal proliferation (Jha et al., 2008)

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Those who may not be a good candidate for GLP-1 medication use severe gastrointestinal diseases (e.g., inflammatory bowel disease) a personal or family history of multiple endocrine neoplasia 2A or 2B a personal or family history of medullary thyroid cancer a history of pancreatitis If youre in perimenopause, pregnancy is still possible, and doctors advise against using semaglutide during pregnancy