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The damaged mitochondrial fragments are then tagged by Pink-1, followed by the recruitment of Parkin which ubiquitinates outer membrane proteins (Narendra et al., 2008)

A pathway model of glucose-stimulated insulin secretion in the pancreatic -cell

SampinoSJuszczakGRZacchiniFSwiergielAHModlinskiJALoiPet al

(2019) conducted a systematic analysis that included pooled data from 12 clinical studies with over 15,000 participants around the world and reported that circulating TMAO concentrations were positively correlated with a high risk of diabetes mellitus, and the odds ratio for T2DM prevalence was reported to increase more than 50% per 5 mol/L rise of plasma TMAO

Although the transfer of metabolic substrates form Schwann cells to axons was reported about two decades ago (Vega et al., 2003), the specific mechanism behind the metabolic transfer in the PNS is still unclear

10.1038/nrm3151 Nat