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Its exceptional stability (acid-pH resistance, enzymatic resistance outperforming most bioactive peptides) enables partial oral bioavailability and a systemic half-life compatible with once-daily administration

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Cardiac symptoms are frequently exertional, worsening with physical activity and improving with rest, though unstable angina or acute coronary syndrome can occur at rest

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Since, the juvenile worms of Isoparorchis hypselobagri penetrate the intestine, liver and swim bladder before transforming into an adult stage, we hypothesise that the migrating juvenile worms cause tissue damage that could result in the down-regulation of antioxidant enzymes

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