McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H
Mounjaro (tirzepatide) operates by mimicking a couple of natural hormones, GLP-1 and GIP
Oxidative stress and diabetes mellitus
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Researchers should approach dosing with appropriate caution and ideally work with knowledgeable healthcare providers
By activating these receptors, tirzepatide: Enhances glucose-dependent insulin secretion from pancreatic beta cells, reducing blood glucose levels without causing hypoglycaemia when glucose levels are normal (though risk increases when used with insulin or sulfonylureas) Suppresses glucagon release from pancreatic alpha cells, further improving glycaemic control Slows gastric emptying , which moderates postprandial glucose excursions, though this effect may diminish over time due to tachyphylaxis Reduces appetite and food intake through central nervous system pathways, contributing to significant weight loss Tirzepatide is administered once weekly via subcutaneous injection, with doses typically titrated from 2
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