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[72] The pathophysiology of BED is not fully understood, but it is believed to involve dysfunctional dopaminergic reward circuitry along the cortico-striatal-thalamic-cortical loop

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It adds that unexpectedly weak appetite suppression or inconsistent glucose response is worth documenting and reporting rather than dismissing

Pilot study: effect of 3,3-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women