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GLP-1s are generally prescribed for adults with type 2 diabetes who have not been able to achieve adequate blood sugar control with oral medications such as metformin

SA could suppress the expression of pro-inflammatory mediators by preventing the activation of inflammatory signaling pathways and regulating macrophage polarization

Crucially, our data reveal that the combination therapy significant elevated endogenous GLP-1 secretion, a result consistent with a recent clinical trial demonstrating that Akk11 supplementation increase serum GLP-1 levels in humans (NCT0665301)

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