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It plays a crucial role in protecting our cells from damage caused by free radicals and toxins

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Supply shortages have been a problem since 2022 due to high demand and the Therapeutic Goods Administration has asked doctors to prioritise diabetes patients over weight loss patients

Here, we report the discovery of a series of fragment hits that bind at the interface between the TRFH domain of TRF1 (TRF1 TRFH ) and a peptide of TIN2 (TIN2 TBM ), an interaction essential for the recruitment of TRF1 to shelterin, using X-ray crystallography (XChem) and ligand-observed NMR (LO-NMR) fragment screening

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