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Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial

doi: 10.3389/fendo.2020.617400 Received 14 October 2020 Accepted 23 November 2020 Published 08 January 2021 Volume 11 - 2020 Edited by Magdalene K

However, severe persistent vomiting (more than 3 episodes per day for more than 2 days), signs of pancreatitis (severe abdominal pain radiating to the back), or allergic reactions (hives, difficulty breathing, facial swelling) warrant immediate protocol cessation and medical attention

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They are particularly useful for recording rare or unexpected clinical outcomes

Nat Methods 12, 78, doi: 10.1038/nmeth.3213 (2015)