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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Dent RB, Vichare A, Casimir J

If confirmed, treatment with semaglutide should not be restarted Gallbladder problems : Rapid weight loss can increase the risk of gallstones, which may cause right upper abdominal pain, fever, or yellowing of the skin/eyes (jaundice) Diabetic retinopathy complications : Patients with existing eye disease should be monitored closely, especially during periods of rapid improvement in blood glucose control [22] [23] Acute kidney injury : Usually associated with severe dehydration from gastrointestinal side effects Allergic reactions, though rare, can occur and may present as rash, itching, or difficulty breathing

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The dual mechanism of action may provide greater resilience against these factors by targeting multiple pathways simultaneously