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HolmanRR,PaulSK,BethelMA,MatthewsDRetal.10-year follow-up of intensive glucose control in type 2 diabetes.N Engl J Med2008;359:15771589

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These PK properties explain fentanyl's rapid onset, limited accumulation compared to morphine, and the need for GA-stratified dosing and frequent reassessment (72, 79, 82)

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