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Another study presented in July 2025 at ENDO 2025, the Endocrine Societys annual meeting, found that a combination of HRT and the hormone therapy helped women maintain a healthy weight

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Biomolecules 13 , 1782 (2023)

The predominant side effects include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (affecting 10-50% of patients depending on the specific product and dose, particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the subcutaneous injection site Hypoglycaemia : particularly when combined with insulin or sulphonylureas Decreased appetite : an intended therapeutic effect that contributes to weight loss However, some patients do report changes in urinary frequency or patterns

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