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The NOX family precisely controls the spatiotemporal production of ROS through multi-layered mechanisms, including subunit assembly [123], phosphorylation [124], regulation of protein stability [125], and SUMOylation [126]
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When mitochondrial function becomes impaired, ROS production may increase while energy production becomes less efficient
The absorbance of each sample was measured at 490 nm using an automated ELISA reader (SpectraMax M5, Molecular Devices, United States)
Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bhm M, et al
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