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The rationale for combining BPC-157 and TB-500 is mechanistic complementarity, not direct evidence

Garbn, H

In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999

Nutrients such as vitamins C and E, flavonoids, polyphenols, and coenzyme Q10 exhibit strong neuroprotective actions

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They added that a peptide called TB-4, and a similar synthetic peptide, TB-500, showed some signs of promoting blood vessel formation and tissue repair in cell studies and animal research, but the experts noted that human data around musculoskeletal conditions are lacking