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In rare cases, more serious reactions such as pancreatitis or kidney problems can occur

However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug

Side effects to tell your doctor about immediately are skin rashes, itching, hives, swelling of the tongue, lips, or face, blueish skin, chest tightness or pain, trouble breathing, wheezing, dizziness, or red, swollen, painful area on a leg (via the Cleveland Clinic)

Not all GLP-1s are approved for obesity treatment, and this analysis includes all FDA-approved GLP-1s, including those approved for obesity (Saxenda, Weogvy, Zepbound) as well as those approved for type 2 diabetes (see Table 1)

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All of the above characteristics contribute to the reduced absorption and distribution of the drug in the body [6,7]