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A 2025 systematic review published in the journal Nutrients, which analyzed data from 38 studies across human and animal models, found that GLP-1 analogues have a notable impact on the composition, richness, and diversity of gut microbiota, though the full picture is still being studied

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[5] REWIND (dulaglutide) : In 9,901 adults with type 2 diabetes, weekly dulaglutide reduced major cardiovascular events by 12% over 5.4 years, benefiting participants with or without prior heart disease

These results suggest that liver-derived FGF21 participates in the promoting effects of beta cell regeneration induced by GCGR mAb

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