Its approval means it has undergone Phase 3 clinical trials, FDA safety review, and ongoing post-market surveillance
Do not freeze it, and avoid leaving it at room temperature for extended periods
On its own, copper can't readily enter cells at useful concentrations
Other GWAS carried out in the Han Chinese identified candidate genes, including (CXCR5/DDX6 at 11q23.3, PMEL/IKZF4 at 12q13.2, and SLC29A3/CDH23 at 10q22.1) (Tang et al., 2013)
The TMLHE gene is located on the X chromosome (Xq28) and is composed of 13 exons that generate two alternatively spliced mRNAs that encode precursor proteins of 421 amino acids (isoform 1) and 376 amino acids (isoform 2)
Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization