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Normal saline presents specific problems for GHK-Cu due to the salt's interference with copper chelation

In particular, oxidative stress reduces the uptake of glutamate in astrocytes, a key step in the recycling of glutamate [16]

Amino Acids GH release is stimulated by a protein meal (526)

By bypassing the digestive tract, IV administration ensures the therapeutic dose reaches target receptors without degradation

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It has since been used in clinical settings for fatigue, muscle spasm, upper respiratory conditions, and immune support