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The balanced dual agonism creates an approximately 8:1 ratio favoring GLP-1R over GCGR activation [4]

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However, given that GLP-1 drugs are understood to engage the hypothalamus, the region of the brain that regulates hormones, appetite, and body temperature, the biological plausibility is real

doi: 10.1016/j.ijcard.2017.03.163 22 SilveriiGAMonamiMMannucciE