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Unlike existing GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic) or dual agonists like tirzepatide (Mounjaro, Zepbound), Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors simultaneously

Liquid options (protein shakes with fruit) are often better tolerated than solid food when appetite is suppressed

A small observational study found that patients who timed injections before their largest meal experienced 812% greater early satiety compared to random timing, though this was not a controlled trial

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Second, the reduction in fat mass, particularly visceral fat, removes a major source of inflammatory cytokine production