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TFA Removal: Processed via acetate exchange to remove inflammatory trifluoroacetic acid salts, ensuring high viability in sensitive cell culture applications

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however, under the weakly acidic conditions of the TME, the cleavage of dimethylmaleic amide results in a positive charge, enabling strong electrostatic interactions with negatively charged oral cancer cell membranes

By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling

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These results indicate that B2M-CuS NPs can specifically eliminate senescent chondrocytes without harming normal chondrocytes