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Serum interleukin-22 (IL-22) is increased in the early stage of Hashimotos thyroiditis compared to non-autoimmune thyroid disease and healthy controls

Comparable results were obtained by the same research group in a subsequent study conducted on 42 patients (39 males and 3 females) using the same maintenance treatment [145]

While researchers continue studying exactly how this impacts bowel function, clinical observations suggest it may compound the constipating effects of GLP-1 activation

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Since metabolic networks are directed, we used relative-betweenness centrality for a metabolite importance measure based on metabolite topology weighed by relative-betweenness centrality 132

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