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The effects of concurrent coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial

Littlejohn and Monrad 2018)

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This finding explains the clinical paradox that giving antioxidants to healthy patients can lead them to develop more cancers than expected. Glutathione and thioredoxin antioxidant pathways synergise to drive cancer initiation and progression

Mechanistically, LONP1 promotes proliferation and migration of pulmonary artery smooth muscle cells by directly binding to and degrading mitochondrial pyruvate carrier 1 (MPC1), leading to pulmonary vascular remodeling and ultimately promoting the development of PH [76]