In published Phase 2 obesity data, the 12 mg group averaged 24.2% body-weight reduction at 48 weeks
For example, GLP-1 (736) has been shown to inhibit cell death processes in cholangiocytes,15 neurons,16 and pancreatic beta cells.17,18 A combination of antiapoptotic and antinecrotic effects has been reported in pancreatic beta cells.19 Such a cytoprotection appears to be due to the direct preservation of mitochondria, as studies in hepatocytes show that GLP-1 (736) exerts insulin-like effects through the modulation of oxidative phosphorylation and the inhibition of oxidative stress.20 A wide variety of cardiovascular actions of GLP-1 have been reported to date, including hemodynamic system changes.21,22 Specifically, cytoprotective actions of GLP-1 (736) have been reported in the heart.2124 In this regard, the fact that different studies show the presence of GLP-1R in the myocardium of different animal models25,26 and in human cardiac tissue27 suggests that GLP-1 (736) may have direct effects on the heart
Neuropeptides1992 Mar;21(3):143-6
Embracing a Holistic Approach Weight loss and management require a holistic approach that combines diet, exercise, and the right supplementation
Support energy and cardiovascular health with Liposomal Liquid B-12. Features active Methyl B12, Hydroxycobalamin, 5-MTHF, and TMG in a sunflower liposomal base
Helpful Tips for Employees Ask your provider to document your diagnosis clearly
