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In studies focusing on Polish patients with AMD, mutations in GPx1 were found, and these mutations lead to weaker antioxidant defense
10.3390/microorganisms7010014 45 SarvanI.van der KlauwM.OlivieroT.DekkerM.VerkerkR
So the theory is if we give that same signal, a hormone at a higher dose, we can overcome whatever that barrier is and it turned out to be true