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These agents are also associated with a minimal risk of hypoglycemia when used as monotherapy or as add-on to metformin monotherapy, but they can contribute to hypoglycemia when used in combination with medications associated with hypoglycemia, such as insulin and insulin secretagogues

External resources SUSTAIN-6 Trial - New England Journal of Medicine : The landmark cardiovascular outcomes trial showing 26% MACE reduction with semaglutide in high-risk type 2 diabetes patients, providing foundational evidence for semaglutide cardiovascular benefit

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Weight changes were modest, typically between a 2 to 6 pound loss over six months

Adults 18 years of age and older with clinically diagnosed CKD, BMI values exceeding 27 kg/m 2 , and UACR between 30-3,500 mg/g were screened for study inclusion

Another study developed phasetransitional Pt (IV) NPcRGD nanoparticles with a hybrid lipidpolymer shell for ovarian cancer, which are both GSHsensitive and ultrasoundresponsive, demonstrating enhanced therapeutic efficacy and reduced side effects in in vivo models [121]