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The recommended daily intake for adults in general is 2.4 micrograms, with older people needing more to make up for decreased absorption

Lanao RPF, Jonker AM, Wolke JGC, Jansen JA, van Hest JCM, Leeuwenburgh SCG

Any disruption of the normal function of the ER, especially oxidative stress, can lead to ER stress, which is characterised by an accumulation of misfolded or unfolded proteins in the ER lumen

Social determinants and health behaviors: conceptual frames and empirical advances

A funnel plot is suggestive of the presence of most of the studies outside the plot, hence it is likely that significant publication bias is present DISCUSSION Obesity has severe health consequences, with each 5 kg/m 2 increase in BMI beyond the normal range linked to a 30% increase in mortality and a potential reduction in life expectancy by up to 10 years.[16] Conversely, significant weight loss is associated with metabolic and non-metabolic benefits