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Functionalization of 3-PLG with l-alanine and l-glutathione The A-GSH-targeted 3-PLGs (3-PLG-A-GSH) were synthesized by grafting A and GSH on 3-PLG using N -ethyl- N -(3-(dimethylamino)propyl)carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling reaction in DIW (Fig

You can, but stability is the challenge

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This suggests the issue may stem from toxic burden, making detoxification crucial

Remarkably, 100% mortality was achieved after 24 hours of exposure at concentrations of 20, 28, and 80 L/L (Xie et al., 2020)

Notes: Chemically related to neostigmine, but has a longer duration of action and less GI effects Pyridostigmine & The 1990-1991 Persian Gulf War Syndrome Because pyridostigmine is a highly ionized quaternary ammonium compound, under normal conditions it does not readily cross the blood-brain barrier (BBB) (Dunn et al, 1997