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Animal models of colitis have demonstrated that GLP-1 receptor activation may reduce intestinal inflammation through multiple mechanisms, including modulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), enhancement of intestinal barrier function, and reduction of oxidative stress

Advanced statistical methodsincluding propensity score adjustment and calibrated hazard ratioswere applied to minimize confounding and enhance reliability

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Given the high global prevalence of obesity and its strong association with type 2 diabetes and other chronic diseases, Retatrutide emerges as a highly promising research candidate