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Differently, administration of Citrobacter rodentium , a bacterium able to disrupt the epithelial barrier, in NOD mice, could increase intestinal permeability, leading to pancreatic insulitis development [60]

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This protective effect was further validated during parthenogenetic activation, where aged oocytes displayed a fragmentation rate reduction of approximately 27% following Epitalon treatment

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This creates a challenging bottleneck for formulators who need to deliver a functional dose to achieve the desired output

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