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1 The management of T2DM is becoming increasingly complex with the availability of more pharmacologic drug classes and the completion of high-quality clinical trials

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GPx2 is specialized for the gastrointestinal tract, mainly located in the cytosol and nucleus, and protects intestinal epithelial cells from oxidative damage

The clinical reality is much narrower than the marketing

The enzyme CHAC1 (CHAC1/BOTCH for blocking NOTCH) is a key regulator of this process (Figure 6)

5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret