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The PI3K/AKT pathway, frequently hyperactivated in cancers due to mutations like those in PIK3CA, drives metabolic reprogramming and enhances antioxidant defenses by stimulating GSH biosynthesis [49]

This includes cysteamine & high strength topical retinoids

These agents may act beyond GLP-1 receptor agonism and may also target pathways involving hormones such as amylin and glucagon

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